IL-33 antibody (AA 112-270)

Catalog No. ABIN7596059

This anti-IL-33 antibody is a Mouse Monoclonal antibody detecting IL-33 in WB, ELISA and FACS. Suitable for Human.

Quick Overview for IL-33 antibody (AA 112-270) (ABIN7596059)

Target: IL-33 (IL33) (Interleukin 33 (IL33))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-33 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: 4E9

Product Details anti-IL-33 Antibody

Binding Specificity: AA 112-270

Purpose: Human IL-33 antibody

Purification: protein-A affinity chromatography

Immunogen: Recombinant human IL-33 (112-270aa) purified from E. coli

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycero

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Target Details for IL-33

Target: IL-33 (IL33) (Interleukin 33 (IL33))

Alternative Name: IL-33

Background: Interleukin 33 (IL-33) is a 32 kDa proinflammatory cytokine and intracellular nuclear factor with transcriptional regulatory properties. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12 kDa and C-terminal fragment of 18 kDa by cleavage of caspase-1.

NCBI Accession: NP_254274

Pathways: Production of Molecular Mediator of Immune Response