Lactate Dehydrogenase A antibody (AA 1-332)

Catalog No. ABIN7596077

This anti-Lactate Dehydrogenase A antibody is a Mouse Monoclonal antibody detecting Lactate Dehydrogenase A in WB, ELISA, IF and ICC. Suitable for Human.

Quick Overview for Lactate Dehydrogenase A antibody (AA 1-332) (ABIN7596077)

Target: Lactate Dehydrogenase A (LDHA)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Lactate Dehydrogenase A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: AT1A4

Product Details anti-Lactate Dehydrogenase A Antibody

Binding Specificity: AA 1-332

Purpose: Human Lactate Dehydrogenase A/LDHA antibody

Purification: protein-A affinity chromatography

Immunogen: Recombinant human LDHA (1-332aa) purified from E.coli

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycero

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Target Details for Lactate Dehydrogenase A

Target: Lactate Dehydrogenase A (LDHA)

Alternative Name: Lactate Dehydrogenase A/LDHA

Background: Lactate through lactate dehydrogenase A (LDHA), which is encoded by a target gene of c-Myc and hypoxia-inducible factor (HIF-1). LDHA expression is repressed by SugR in the absence of sugar. Reduction of LDHA causes bioenergetic and oxidative stress leading to cell death. LDHA (LDH-5, M-LDH, or A4), which is the predominant form in skeletal muscle, kinetically favors the conversion of pyruvate to lactate. Therefore, LDH-A is an attractive target for cancer therapy since its expression is largely relegated to skeletal muscle.

NCBI Accession: NP_005557

Pathways: Warburg Effect