Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

PAK2 antibody (AA 1-288)

This anti-PAK2 antibody is a Rabbit Polyclonal antibody detecting PAK2 in WB, ELISA, IHC, IF, FACS and ICC. Suitable for Human, Mouse and Rat.
Catalog No. ABIN7599219

Quick Overview for PAK2 antibody (AA 1-288) (ABIN7599219)

Target

See all PAK2 Antibodies
PAK2 (P21-Activated Kinase 2 (PAK2))

Reactivity

  • 94
  • 46
  • 44
  • 3
  • 1
  • 1
Human, Mouse, Rat

Host

  • 91
  • 4
Rabbit

Clonality

  • 80
  • 15
Polyclonal

Conjugate

  • 62
  • 5
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 1
  • 1
  • 1
  • 1
This PAK2 antibody is un-conjugated

Application

  • 61
  • 49
  • 29
  • 16
  • 5
  • 5
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)
  • Binding Specificity

    • 12
    • 12
    • 11
    • 8
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-288

    Purpose

    Anti-PAK2 Antibody Picoband®

    Cross-Reactivity (Details)

    No cross-reactivity with other proteins.

    Characteristics

    Anti-PAK2 Antibody Picoband® (ABIN7599219). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Purification

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human PAK2 recombinant protein (Position: M1-K288).

    Isotype

    IgG
  • Application Notes

    Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat
    Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Bokoch, G. M. Caspase-mediated activation of PAK2 during apoptosis: proteolytic kinase activation as a general mechanism of apoptotic signal transduction? Cell Death Diff. 5: 637-645, 1998. 2. Choi, J., Pease, D. R., Chen, S., Zhang, B., Phee, H. P21-activated kinase 2 is essential in maintenance of peripheral Foxp3+ regulatory T cells. Immunology 154: 309-321, 2018. 3. Eswaran, J., Soundararajan, M., Kumar, R., Knapp, S. UnPAKing the class differences among p21-activated kinases. Trends Biochem. Sci. 33: 394-403, 2008.

    Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Concentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Storage

    4 °C,-20 °C

    Storage Comment

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    PAK2 (P21-Activated Kinase 2 (PAK2))

    Alternative Name

    PAK2

    Background

    Synonyms: Protein arginine N-methyltransferase 1, Histone-arginine N-methyltransferase PRMT1, Interferon receptor 1-bound protein 4, PRMT1, HMT2, HRMT1L2, IR1B4

    Tissue Specificity: Widely expressed (PubMed:11097842). Expressed strongly in colorectal cancer cells (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (PubMed:28040436).

    Background: Serine/threonine-protein kinase PAK 2 is an enzyme that in humans is encoded by the PAK2 gene. The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.

    Molecular Weight

    58 kDa

    Gene ID

    5062

    UniProt

    Q13177

    Pathways

    MAPK Signaling, RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
You are here:
Chat with us!