TP53I3 antibody (AA 1-332)

Catalog No. ABIN7599280

This Rabbit Polyclonal antibody specifically detects TP53I3 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for TP53I3 antibody (AA 1-332) (ABIN7599280)

Target: TP53I3 (Tumor Protein P53 Inducible Protein 3 (TP53I3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TP53I3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-TP53I3 Antibody

Binding Specificity: AA 1-332

Purpose: Anti-PIG3/TP53I3 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-PIG3/TP53I3 Antibody Picoband® (ABIN7599280). Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PIG3/TP53I3 recombinant protein (Position: M1-Q332).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.25 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 1-2 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Contente, A., Dittmer, A., Koch, M. C., Roth, J., Dobbelstein, M. A polymorphic microsatellite that mediates induction of PIG3 by p53. Nature Genet. 30: 315-320, 2002. 2. Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., Vogelstein, B. A model for p53-induced apoptosis. Nature 389: 300-305, 1997.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for TP53I3

Target: TP53I3 (Tumor Protein P53 Inducible Protein 3 (TP53I3))

Alternative Name: TP53I3

Background:

Synonyms: Angiomotin-like protein 2, Leman coiled-coil protein, LCCP, AMOTL2, KIAA0989

Background: Putative quinone oxidoreductase is an enzyme that in humans is encoded by the TP53I3 gene. The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats ly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 36 kDa

Gene ID: 9540

Pathways: p53 Signaling