Macrophage Scavenger Receptor 1 antibody (AA 1-451)

Catalog No. ABIN7599407

The Rabbit Polyclonal anti-Macrophage Scavenger Receptor 1 antibody has been validated for WB, ELISA and FACS. It is suitable to detect Macrophage Scavenger Receptor 1 in samples from Mouse.

Quick Overview for Macrophage Scavenger Receptor 1 antibody (AA 1-451) (ABIN7599407)

Target: Macrophage Scavenger Receptor 1 (MSR1)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Macrophage Scavenger Receptor 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-Macrophage Scavenger Receptor 1 Antibody

Binding Specificity: AA 1-451

Purpose: Anti-CD204/Msr1 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-/Msr1 Antibody Picoband® (ABIN7599407). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse CD204/Msr1 recombinant protein (Position: M1-D451).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Mouse
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Mouse
ELISA, 0.1-0.5 μg/mL, -
1. Gross, M. B. Personal Communication. Baltimore, Md. 9/30/2015. 2. Hemmasi, S., Czulkies, B. A., Schorch, B., Veit, A., Aktories, K., Papatheodorou, P. Interaction of the Clostridium difficile binary toxin CDT and its host cell receptor, lipolysis-stimulated lipoprotein receptor (LSR). J. Biol. Chem. 290: 14031-14044, 2015. 3. Maddirevula, S., Alhebbi, H., Alqahtani, A., Algoufi, T., Alsaif, H. S., Ibrahim, N., Abdulwahab, F., Barr, M., Alzaidan, H., Almehaideb, A., AlSasi, O., Alhashem, A., Al-Hussaini, H., Wali, S., Alkuraya, F. S. Identification of novel loci for pediatric cholestatic liver disease defined by KIF12, PPM1F, USP53, LSR, and WDR83OS pathogenic variants. Genet. Med. 21: 1164-1172, 2019.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for Macrophage Scavenger Receptor 1

Target: Macrophage Scavenger Receptor 1 (MSR1)

Alternative Name: Msr1

Background:

Synonyms: Acid-sensing ion channel 1, ASIC1,Amiloride-sensitive cation channel 2, neuronal, Brain sodium channel 2, BNaC2, ASIC1, ACCN2, BNAC2

Tissue Specificity: Expressed in most or all neurons.

Background: Macrophage scavenger receptor 1, also known as MSR1, is a protein which in humans is encoded by the MSR1 gene. Enables amyloid-beta binding activity, cargo receptor activity, and low-density lipoprotein particle binding activity. Involved in several processes, including endocytosis, positive regulation of cholesterol storage, and positive regulation of macrophage derived foam cell differentiation. Acts upstream of or within lipoprotein transport. Located in plasma membrane. Is expressed in several structures, including alimentary system, limb, neural tube, reproductive system, and yolk sac. Human ortholog(s) of this gene implicated in Barrett's esophagus, arteriosclerosis, and prostate cancer. Orthologous to human MSR1 (macrophage scavenger receptor 1).

Molecular Weight: 75-90 kDa

Gene ID: 20288

UniProt: P30204