CBX2 antibody (AA 1-532)

Catalog No. ABIN7599466

This Rabbit Polyclonal antibody specifically detects CBX2 in WB, ELISA, IHC, IF and ICC. It exhibits reactivity toward Human and Mouse.

Quick Overview for CBX2 antibody (AA 1-532) (ABIN7599466)

Target: CBX2 (Chromobox Homolog 2 (CBX2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBX2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-CBX2 Antibody

Binding Specificity: AA 1-532

Purpose: Anti-CBX2 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-CBX2 Antibody Picoband® (ABIN7599466). Tested in ELISA, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CBX2 recombinant protein (Position: M1-Y532).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Biason-Lauber, A., Konrad, D., Meyer, M., deBeaufort, C., Schoenle, E. J. Ovaries and female phenotype in a girl with 46,XY karyotype and mutations in the CBX2 gene. Am. J. Hum. Genet. 84: 658-663, 2009. 2. Gecz, J., Gaunt, S. J., Passage, E., Burton, R. D., Cudrey, C., Pearce, J. J. H., Fontes, M. Assignment of a polycomb-like chromobox gene (CBX2) to human chromosome 17q25. Genomics 26: 130-133, 1995. 3. Katoh-Fukui, Y., Tsuchiya, R., Shiroishi, T., Nakahara, Y., Hashimoto, N., Noguchi, K., Higashinakagawa, T. Male-to-female sex reversal in M33 mutant mice. Nature 393: 688-692, 1998.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for CBX2

Target: CBX2 (Chromobox Homolog 2 (CBX2))

Alternative Name: CBX2

Background:

Synonyms: Rho-related GTP-binding protein Rho6,Rho family GTPase 1,Rnd1,RND1,RHO6,

Tissue Specificity: Mostly expressed in brain and liver.

Background: Chromobox protein homolog 2 is a protein that in humans is encoded by the CBX2 gene. This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Molecular Weight: 56 kDa

Gene ID: 84733

UniProt: Q14781