VEGFC antibody (AA 108-223)

Catalog No. ABIN7599683

The Rabbit Polyclonal anti-VEGFC antibody has been validated for WB and ELISA. It is suitable to detect VEGFC in samples from Mouse and Rat.

Quick Overview for VEGFC antibody (AA 108-223) (ABIN7599683)

Target: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VEGFC antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-VEGFC Antibody

Binding Specificity: AA 108-223

Purpose: Anti-Vegfc Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Vegfc Antibody Picoband® (ABIN7599683). Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Vegfc recombinant protein (Position: A108-R223).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Balboa-Beltran, E., Fernandez-Seara, M. J., Perez-Munuzuri, A., Lago, R., Garcia-Magan, C., Couce, M. L., Sobrino, B., Amigo, J., Carracedo, A., Barros, F. A novel stop mutation in the vascular endothelial growth factor-C gene (VEGFC) results in Milroy-like disease. J. Med. Genet. 51: 475-478, 2014. Note: Erratum: J. Med. Genet. 52: 216 only, 2015. 2. Gordon, K., Schulte, D., Brice, G., Simpson, M. A., Roukens, M. G., van Impel, A., Connell, F., Kalidas, K., Jeffery, S., Mortimer, P. S., Mansour, S., Schulte-Merker, S., Ostergaard, P. Mutation in vascular endothelial growth factor-C, a ligand for vascular endothelial growth factor receptor-3, is associated with autosomal dominant Milroy-like primary lymphedema. Circ. Res. 112: 956-960, 2013. 3. Hung, C. J., Ginzinger, D. G., Zarnegar, R., Kanauchi, H., Wong, M. G., Kebebew, E., Clark, O. H., Duh, Q.-Y. Expression of vascular endothelial growth factor-C in benign and malignant thyroid tumors. J. Clin. Endocr. Metab. 88: 3694-3699, 2003.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for VEGFC

Target: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Alternative Name: Vegfc

Background:

Synonyms: Tyrosine aminotransferase,TAT,2.6.1.5,L-tyrosine:2-oxoglutarate aminotransferase,TAT,

Background: Vascular endothelial growth factor C (VEGF-C) is a protein that is a member of the platelet-derived growth factor / vascular endothelial growth factor (PDGF/VEGF) family. It is encoded in humans by the VEGFC gene, which is located on chromosome 4q34. Enables vascular endothelial growth factor receptor 3 binding activity. Involved in several processes, including negative regulation of osteoblast differentiation, positive regulation of angiogenesis, and positive regulation of mesenchymal stem cell proliferation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor, positive regulation of lymphangiogenesis, and positive regulation of peptidyl-tyrosine phosphorylation. Located in extracellular space. Is expressed in several structures, including alimentary system mesentery, brain, cardiovascular system, embryo mesenchyme, and genitourinary system. Used to study hereditary lymphedema. Human ortholog(s) of this gene implicated in breast carcinoma and hereditary lymphedema ID. Orthologous to human VEGFC (vascular endothelial growth factor C).

Molecular Weight: 46 kDa

Gene ID: 22341

UniProt: P97953

Pathways: RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2