TRF1 antibody (AA 119-341)

Catalog No. ABIN7599802

This anti-TRF1 antibody is a Rabbit Polyclonal antibody detecting TRF1 in WB, ELISA, ICC and IF. Suitable for Human.

Quick Overview for TRF1 antibody (AA 119-341) (ABIN7599802)

Target: TRF1 (TERF1) (Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRF1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-TRF1 Antibody

Binding Specificity: AA 119-341

Purpose: Anti-TRF1/TERF1 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-TRF1/TERF1 Antibody Picoband® (ABIN7599802). Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human TRF1/TERF1 recombinant protein (Position: Q119-R341).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Broccoli, D., Chong, L., Oelmann, S., Fernald, A. A., Marziliano, N., van Steensel, B., Kipling, D., Le Beau, M. M., de Lange, T. Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domains. Hum. Molec. Genet. 6: 69-76, 1997. 2. Chen, Y., Yang, Y., van Overbeek, M., Donigian, J. R., Baciu, P., de Lange, T., Lei, M. A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science 319: 1092-1096, 2008. 3. Chong, L., van Steensel, B., Broccoli, D., Erdjument-Bromage, H., Hanish, J., Tempst, P., de Lange, T. A human telomeric protein. Science 270: 1663-1667, 1995.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for TRF1

Target: TRF1 (TERF1) (Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1))

Alternative Name: TERF1

Background:

Synonyms: Angiopoietin-like protein 8 ,Betatrophin ,Lipasin ,Refeeding-induced fat and liver protein ,ANGPTL8 ,C19orf80, RIFL ,UNQ599/PRO1185 ,

Tissue Specificity: Predominantly expressed in liver. Also expressed in adipose tissues. .

Background: Telomeric repeat-binding factor 1 is a protein that in humans is encoded by the TERF1 gene. This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.

Molecular Weight: 55 kDa

Gene ID: 7013

UniProt: P54274

Pathways: Cell Division Cycle, Telomere Maintenance, Hormone Transport, Chromatin Binding, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity