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Tricellulin antibody (AA 12-496)

This Rabbit Polyclonal antibody specifically detects Tricellulin in WB, IHC, ELISA and FACS. It exhibits reactivity toward Human and Rat.
Catalog No. ABIN7599821

Quick Overview for Tricellulin antibody (AA 12-496) (ABIN7599821)

Target

See all Tricellulin (MARVELD2) Antibodies
Tricellulin (MARVELD2)

Reactivity

  • 28
  • 11
  • 10
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Rat

Host

  • 28
Rabbit

Clonality

  • 28
Polyclonal

Conjugate

  • 15
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This Tricellulin antibody is un-conjugated

Application

  • 20
  • 11
  • 10
  • 3
  • 2
  • 2
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)
  • Binding Specificity

    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 12-496

    Purpose

    Anti-MARVELD2 Antibody Picoband®

    Characteristics

    Anti-MARVELD2 Antibody Picoband® (ABIN7599821). Tested in WB, IHC, Flow Cytometry, ELISA applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Purification

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human MARVELD2 recombinant protein (Position: R12-H496). Human MARVELD2 shares 87% amino acid (aa) sequence identity with mouse MARVELD2.
  • Application Notes

    Western blot, 0.25-0.5 μg/mL, Human, Rat
    Immunohistochemistry, 2-5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Chishti, M. S., Bhatti, A., Tamim, S., Lee, K., McDonald, M.-L., Leal, S. M., Ahmad, W. Splice-site mutations in the TRIC gene underlie autosomal recessive nonsyndromic hearing impairment in Pakistani families. J. Hum. Genet. 53: 101-105, 2008. 2. Ikenouchi, J., Furuse, M., Furuse, K., Sasaki, H., Tsukita, S., Tsukita, S. Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. J. Cell Biol. 171: 939-945, 2005. 3. Riazuddin, S., Ahmed, Z. M., Fanning, A. S., Lagziel, A., Kitajiri, S., Ramzan, K., Khan, S. N., Chattaraj, P., Friedman, P. L., Anderson, J. M., Belyantseva, I. A., Forge, A., Riazuddin, S., Friedman, T. B. Tricellulin is a tight-junction protein necessary for hearing. Am. J. Hum. Genet. 79: 1040-1051, 2006.

    Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Concentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Storage

    4 °C,-20 °C

    Storage Comment

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    Tricellulin (MARVELD2)

    Alternative Name

    MARVELD2

    Background

    MARVEL domain-containing protein 2 is a protein that in humans is encoded by the MARVELD2 gene. The protein encoded by this gene is a membrane protein found at the tight junctions between epithelial cells. The encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49). Two transcript variants encoding different isoforms have been found for this gene.

    Molecular Weight

    64 kDa

    Gene ID

    153562

    UniProt

    Q8N4S9

    Pathways

    Sensory Perception of Sound, Cell-Cell Junction Organization
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