CBR1 antibody (AA 14-262)

Catalog No. ABIN7600015

This anti-CBR1 antibody is a Rabbit Polyclonal antibody detecting CBR1 in WB, ELISA, IHC, ICC, IF and FACS. Suitable for Human, Mouse and Rat.

Quick Overview for CBR1 antibody (AA 14-262) (ABIN7600015)

Target: CBR1 (Carbonyl Reductase 1 (CBR1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-CBR1 Antibody

Binding Specificity: AA 14-262

Purpose: Anti-CBR1 Picoband® Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-CBR1 Picoband® Antibody (ABIN7600015). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CBR1 recombinant protein (Position: N14-E262).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human, Mouse
ELISA, 0.1-0.5 μg/mL, -
1. Avramopoulos, D., Cox, T., Forrest, G. L., Chakravarti, A., Antonarakis, S. E. Linkage mapping of the carbonyl reductase (CBR) gene on human chromosome 21 using a DNA polymorphism in the 3-prime untranslated region. Genomics 13: 447-448, 1992. 2. Forrest, G. L., Akman, S., Krutzik, S., Paxton, R. J., Sparkes, R. S., Doroshow, J., Felsted, R. L., Glover, C. J., Mohandas, T., Bachur, N. R. Induction of a human carbonyl reductase gene located on chromosome 21. Biochim. Biophys. Acta 1048: 149-155, 1990. 3. Lemieux, N., Malfoy, B., Forrest, G. L. Human carbonyl reductase (CBR) localized to band 21q22.1 by high-resolution fluorescence in situ hybridization displays gene dosage effects in trisomy 21 cells. Genomics 15: 169-172, 1993.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for CBR1

Target: CBR1 (Carbonyl Reductase 1 (CBR1))

Alternative Name: CBR1

Background:

Synonyms: Carbonyl reductase [NADPH] 1, 15-hydroxyprostaglandin dehydrogenase [NADP (+)], NADPH-dependent carbonyl reductase 1, Prostaglandin 9-ketoreductase, Prostaglandin-E (2) 9-reductase, Short chain dehydrogenase/reductase family 21C member 1, CBR1, CBR, CRN, SDR21C1

Tissue Specificity: Highly expressed in spleen. Also detected in liver, placenta, lung, peripheral blood leukocytes and in brain.

Background: Carbonyl reductase 1, also known as CBR1, is an enzyme which in humans is encoded by the CBR1 gene. It is mapped to 21q22.12. The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene.

Molecular Weight: 36 kDa

Gene ID: 873

UniProt: P16152