IL-21 antibody (AA 18-146)

Catalog No. ABIN7600316

This anti-IL-21 antibody is a Rabbit Polyclonal antibody detecting IL-21 in ELISA and IHC. Suitable for Mouse and Rat.

Quick Overview for IL-21 antibody (AA 18-146) (ABIN7600316)

Target: IL-21 (IL21) (Interleukin 21 (IL21))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-21 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-IL-21 Antibody

Binding Specificity: AA 18-146

Purpose: Anti-IL-21/Il21 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-IL-21/Il21 Antibody Picoband® (ABIN7600316). Tested in ELISA, IHC applications. This antibody reacts with Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse IL-21/Il21 recombinant protein (Position: H18-S146).

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Berglund, L. J., Avery, D. T., Ma, C. S., Moens, L., Deenick, E. K., Bustamante, J., Boisson-Dupuis, S., Wong, M., Adelstein, S., Arkwright, P. D., Bacchetta, R., Bezrodnik, L., and 12 others. IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts. Blood 122: 3940-3950, 2013. 2. Brandt, K., Singh, P. B., Bulfone-Paus, S., Ruckert, R. Interleukin-21: a new modulator of immunity, infection, and cancer. Cytokine Growth Factor Rev. 18: 223-232, 2007. 3. Brodeur, T. Y., Robidoux, T. E., Weinstein, J. S., Craft, J., Swain, S. L., Marshak-Rothstein, A. IL-21 promotes pulmonary fibrosis through the induction of profibrotic CD8+ T cells. J. Immun. 195: 5251-5260, 2015.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.005 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for IL-21

Target: IL-21 (IL21) (Interleukin 21 (IL21))

Alternative Name: Il21

Background:

Synonyms: Beta-2-microglobulin, B2m

Tissue Specificity: Detected in lung, spleen, uterus, vagina and epididymis. .

Background: Interleukin 21 (IL-21) is a protein that in humans is encoded by the IL21 gene. This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Molecular Weight: 65-80 kDa

Gene ID: 60505

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response