FGF3 antibody (AA 18-239)

Catalog No. ABIN7600325

This anti-FGF3 antibody is a Rabbit Polyclonal antibody detecting FGF3 in IHC and ELISA. Suitable for Human.

Quick Overview for FGF3 antibody (AA 18-239) (ABIN7600325)

Target: FGF3 (Fibroblast Growth Factor 3 (FGF3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGF3 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-FGF3 Antibody

Binding Specificity: AA 18-239

Purpose: Anti-FGF3 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-FGF3 Antibody Picoband® (ABIN7600325). Tested in ELISA, IHC applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human FGF3 recombinant protein (Position: A18-H239).

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Alsmadi, O., Meyer, B. F., Alkuraya, F, Wakil, S., Alkayal, F., Al-Saud, H., Ramzan, K., Al-Sayed, M. Syndromic congenital sensorineural deafness, microtia and microdontia resulting from a novel homoallelic mutation in fibroblast growth factor 3 (FGF3). Europ. J. Hum. Genet. 17: 14-21, 2009. 2. Brookes, S., Smith, R., Casey, G., Dickson, C., Peters, G. Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells. Oncogene 4: 429-436, 1989. 3. Casey, G., Smith, R., McGillivray, D., Peters, G., Dickson, C. Characterization and chromosome assignment of the human homolog of int-2, a potential proto-oncogene. Molec. Cell. Biol. 6: 502-510, 1986.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for FGF3

Target: FGF3 (Fibroblast Growth Factor 3 (FGF3))

Alternative Name: FGF3

Background:

Synonyms: Glutathione S-transferase Mu 3, GST class-mu 3, GSTM3-3, hGSTM3-3, GSTM3, GST5,

Tissue Specificity: Testis and brain.

Background: INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.

Molecular Weight: 33 kDa

Gene ID: 2248

UniProt: P11487

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway