PTPN12 antibody (AA 276-311)

Catalog No. ABIN7601051

The Rabbit Polyclonal anti-PTPN12 antibody (ABIN7601051) specifically detects PTPN12 in WB, ELISA and FACS. The antibody is reactive with Human samples.

Quick Overview for PTPN12 antibody (AA 276-311) (ABIN7601051)

Target: PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPN12 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-PTPN12 Antibody

Binding Specificity: AA 276-311

Purpose: Anti-PTPN12 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-PTPN12 Antibody (ABIN7601051). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PTPN12 recombinant protein (Position: A276-D311).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for PTPN12

Target: PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))

Alternative Name: PTPN12

Background:

Synonyms: Platelet basic protein, PBP, C-X-C motif chemokine 7, Leukocyte-derived growth factor, LDGF, Macrophage-derived growth factor, MDGF, Small-inducible cytokine B7, PPBP, CTAP3, CXCL7, SCYB7, TGB1, THBGB1, NAP-2

Background: Tyrosine-protein phosphatase non-receptor type 12 is an enzyme that in humans is encoded by the PTPN12 gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Molecular Weight: 110 kDa

Gene ID: 5782

UniProt: Q05209