NUMBL antibody (AA 336-537)

Catalog No. ABIN7601366

This anti-NUMBL antibody is a Rabbit Polyclonal antibody detecting NUMBL in WB, ELISA and FACS. Suitable for Human, Mouse and Rat.

Quick Overview for NUMBL antibody (AA 336-537) (ABIN7601366)

Target: NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUMBL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-NUMBL Antibody

Binding Specificity: AA 336-537

Purpose: Anti-NUMBL Antibody Picoband®

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Anti-NUMBL Antibody Picoband® (ABIN7601366). Tested in ELISA, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NUMBL recombinant protein (Position: R336-A537). Human NUMBL shares 91.1% and 89.4% amino acid (aa) sequence identity with mouse and rat NUMBL, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Huang, E. J., Li, H., Tang, A. A., Wiggins, A. K., Neve, R. L., Zhong, W., Jan, L. Y., Jan, Y. N. Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes Dev. 19: 138-151, 2005. 2. Li, H.-S., Wang, D., Shen, Q., Schonemann, M. D., Gorski, J. A., Jones, K. R., Temple, S., Jan, L. Y., Jan, Y. N. Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron 40: 1105-1118, 2003. 3. Margolis, R. L., Abraham, M. R., Gatchell, S. B., Li, S.-H., Kidwai, A. S., Breschel, T. S., Stine, O. C., Callahan, C., McInnis, M. G., Ross, C. A. cDNAs with long CAG trinucleotide repeats from human brain. Hum. Genet. 100: 114-122, 1997.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for NUMBL

Target: NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))

Alternative Name: NUMBL

Background:

Synonyms: 70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70(S6K) alpha antibody, p70(S6K)-alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70 kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody

Tissue Specificity: Expressed in all tissues.

Background: Numb-like protein is a protein that in humans is encoded by the NUMBL gene. NUMBL [numb (drosophila) homolog-like] is functionally related to NUMB, a protein that plays an essential role in the determination of cell fate for sensory organ and neural development. Polyglutamine repeats in the NUMBL gene have been associated with schizophrenia in two unrelated populations. Alternate names for NUMBL include NBL, CAG3A, CTG3a, NUMBR, TNRC23, and NUMBLIKE.

Molecular Weight: 72 kDa

Gene ID: 9253

UniProt: Q9Y6R0

Pathways: Cell-Cell Junction Organization