WHSC1L1 antibody (AA 46-1425)

Catalog No. ABIN7601791

The Rabbit Polyclonal anti-WHSC1L1 antibody has been validated for WB and ELISA. It is suitable to detect WHSC1L1 in samples from Human and Monkey.

Quick Overview for WHSC1L1 antibody (AA 46-1425) (ABIN7601791)

Target: WHSC1L1 (Wolf-Hirschhorn Syndrome Candidate 1-Like 1 (WHSC1L1))

Reactivity: Human, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WHSC1L1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-WHSC1L1 Antibody

Binding Specificity: AA 46-1425

Purpose: Anti-NSD3 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-NSD3 Antibody Picoband® (ABIN7601791). Tested in ELISA, WB applications. This antibody reacts with Human, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NSD3 recombinant protein (Position: Q46-K1425).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Monkey
ELISA, 0.1-0.5 μg/mL, -
1. Angrand, P.-O., Apiou, F., Stewart, A. F., Dutrillaux, B., Losson, R., Chambon, P. NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines. Genomics 74: 79-88, 2001. 2. Rosati, R., La Starza, R., Veronese, A., Aventin, A., Schwienbacher, C., Vallespi, T., Negrini, M., Martelli, M. F., Mecucci, C. NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8,11)(p11.2,p15). Blood 99: 3857-3860, 2002. Note: Erratum: Blood 100: 1132 only, 2002. 3. Stec, I., van Ommen, G.-J. B., den Dunnen, J. T. WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and maps to a duplicated region shared with 4p16.3. Genomics 76: 5-8, 2001.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for WHSC1L1

Target: WHSC1L1 (Wolf-Hirschhorn Syndrome Candidate 1-Like 1 (WHSC1L1))

Alternative Name: NSD3

Background:

Synonyms: Protein Bop, BH3-only protein, Retrotransposon Gag-like protein 10, RTL10, BOP, C22orf29

Tissue Specificity: Ubiquitously expressed.

Background: Histone-lysine N-methyltransferase NSD3 is an enzyme that in humans is encoded by the WHSC1L1 gene. This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described.

Molecular Weight: 90 kDa

Gene ID: 54904