XRN2 antibody (AA 5-748)

Catalog No. ABIN7601894

This anti-XRN2 antibody is a Rabbit Polyclonal antibody detecting XRN2 in WB, ELISA and FACS. Suitable for Human.

Quick Overview for XRN2 antibody (AA 5-748) (ABIN7601894)

Target: XRN2 (5'-3' Exoribonuclease 2 (XRN2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XRN2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-XRN2 Antibody

Binding Specificity: AA 5-748

Purpose: Anti-XRN2 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-XRN2 Antibody Picoband® (ABIN7601894). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human XRN2 recombinant protein (Position: A5-N748).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Chatterjee, S., Grosshans, H. Active turnover modulates mature microRNA activity in Caenorhabditis elegans. Nature 461: 546-549, 2009. 2. Shobuike, T., Sugano, S., Yamashita, T., Ikeda, H. Characterization of cDNA encoding mouse homolog of fission yeast dhp1+ gene: structural and functional conservation. Nucleic Acids Res. 23: 357-361, 1995. 3. West, S., Gromak, N., Proudfoot, N. J. Human 5-prime to 3-prime exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites. Nature 432: 522-525, 2004.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for XRN2

Target: XRN2 (5'-3' Exoribonuclease 2 (XRN2))

Alternative Name: XRN2

Background:

Synonyms: Proliferation-associated protein 2G4,Cell cycle protein p38-2G4 homolog,hG4-1,ErbB3-binding protein 1,PA2G4,EBP1,

Tissue Specificity: Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver. .

Background: 5'-3' Exoribonuclease 2 (XRN2) also known as Dhm1-like protein is an exoribonuclease enzyme that in humans is encoded by the XRN2 gene. This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight: 109 kDa

Gene ID: 22803

UniProt: Q9H0D6