LEMD3 antibody (AA 535-852)

Catalog No. ABIN7601987

The Rabbit Polyclonal anti-LEMD3 antibody (ABIN7601987) specifically detects LEMD3 in WB, FACS and ELISA. The antibody is reactive with Human samples.

Quick Overview for LEMD3 antibody (AA 535-852) (ABIN7601987)

Target: LEMD3 (LEM Domain Containing 3 (LEMD3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LEMD3 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), ELISA

Product Details anti-LEMD3 Antibody

Binding Specificity: AA 535-852

Purpose: Anti-LEMD3 Antibody

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Anti-LEMD3 Antibody. Tested in ELISA, WB, Flow Cytometry applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human LEMD3 recombinant protein (Position: H535-H852).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for LEMD3

Target: LEMD3 (LEM Domain Containing 3 (LEMD3))

Alternative Name: LEMD3

Background:

Background: LEM domain-containing protein 3 (LEMD3), also known as MAN1, is an integral protein in the inner nuclear membrane (INM) of the nuclear envelope. It is encoded by the LEMD3 gene[5] and was first identified after it was isolated from the serum of a patient with a collagen vascular disease. This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.

Gene Full Name: LEM domain containing 3

Molecular Weight: 120 kDa

Gene ID: 23592

UniProt: Q9Y2U8