EDEM3 antibody (AA 54-795)

Catalog No. ABIN7602003

Product Details anti-EDEM3 Antibody

Target: EDEM3 (ER Degradation Enhancer, Mannosidase alpha-Like 3 (EDEM3))

Binding Specificity: AA 54-795

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EDEM3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purpose: Anti-EDEM3 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-EDEM3 Antibody Picoband® (ABIN7602003). Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human EDEM3 recombinant protein (Position: N54-D795).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Hirao, K., Natsuka, Y., Tamura, T., Wada, I., Morito, D., Natsuka, S., Romero, P., Sleno, B., Tremblay, L. O., Herscovics, A., Nagata, K., Hosokawa, N. EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming. J. Biol. Chem. 281: 9650-9658, 2006. 2. Sood, R., Bonner, T. I., Makalowska, I., Stephan, D. A., Robbins, C. M., Connors, T. D., Morgenbesser, S. D., Su, K., Faruque, M. U., Pinkett, H., Graham, C., Baxevanis, A. D., Klinger, K. W., Landes, G. M., Trent, J. M., Carpten, J. D. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. Genomics 73: 211-222, 2001.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for EDEM3

Target: EDEM3 (ER Degradation Enhancer, Mannosidase alpha-Like 3 (EDEM3))

Alternative Name: EDEM3 (EDEM3 Products)

Background:

Synonyms: Pre T-cell antigen receptor alpha, pT-alpha, pTa, pT-alpha-TCR, PTCRA

Tissue Specificity: Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.

Background: ER degradation-enhancing alpha-mannosidase-like 3 is an enzyme that in humans is encoded by the EDEM3 gene. Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER.

Molecular Weight: 105 kDa

Gene ID: 80267

Pathways: SARS-CoV-2 Protein Interactome