CDCP1 antibody (AA 74-580)

Catalog No. ABIN7602404

The Rabbit Polyclonal anti-CDCP1 antibody (ABIN7602404) specifically detects CDCP1 in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for CDCP1 antibody (AA 74-580) (ABIN7602404)

Target: CDCP1 (CUB Domain Containing Protein 1 (CDCP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDCP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CDCP1 Antibody

Binding Specificity: AA 74-580

Purpose: Anti-CDCP1 Antibody

Predicted Reactivity: Human CDCP1 shares 85.8% amino acid (aa) sequence identity with mouse CDCP1.

Characteristics: Anti-CDCP1 Antibody. Tested in WB, ELISA applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CDCP1 recombinant protein (Position: E74-V580). Human CDCP1 shares 85.8% amino acid (aa) sequence identity with mouse CDCP1.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CDCP1

Target: CDCP1 (CUB Domain Containing Protein 1 (CDCP1))

Alternative Name: CDCP1

Background:

Background: CUB domain-containing protein 1 (CDCP1) is a protein that in humans is encoded by the CDCP1 gene. It has also been designated as CD318 (cluster of differentiation 318) and Trask (Transmembrane and associated with src kinases). CDCP1/Trask is a 140 kD transmembrane glycoprotein with a large extracellular domain (ECD) containing two CUB domains, and a smaller intracellular domain (ICD) containing five tyrosines. The tyrosine phosphorylation of Trask is tightly regulated and reciprocally linked with the state of cell adhesion. The tyrosine phosphorylation of CDCP1 in cultured cells occurs when cells are induced to detach by trypsin or EDTA, or seen spontaneously during mitotic detachment. The overexpression of CDCP1 leads to the loss of cell adhesion and a detached phenotype. CDCP1 is widely expressed in human epithelial tissues, but its phosphorylation is only seen in mitotically detached or shedding cells, consistent with its role in the negative regulation of cell adhesion.

Gene Full Name: CUB domain containing protein 1

Molecular Weight: 130 kDa

Gene ID: 64866

UniProt: Q9H5V8