Factor XI antibody (AA 79-155)

Catalog No. ABIN7602456

This Rabbit Polyclonal antibody specifically detects Factor XI in WB, ICC, ELISA, FACS and IF. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for Factor XI antibody (AA 79-155) (ABIN7602456)

Target: Factor XI (F11) (Coagulation Factor XI (F11))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Factor XI antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)

Product Details anti-Factor XI Antibody

Binding Specificity: AA 79-155

Purpose: Anti-FXI/F11 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-FXI/F11 Antibody. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human FXI/F11 recombinant protein (Position: K79-Q155).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Factor XI

Target: Factor XI (F11) (Coagulation Factor XI (F11))

Alternative Name: F11

Background:

Background: Factor XI or plasma thromboplastin antecedent is the zymogen form of factor XIa, one of the enzymes of the coagulation cascade. Like many other coagulation factors, it is a serine protease. In humans, Factor XI is encoded by the F11 gene. This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.

Gene Full Name: coagulation factor XI

Molecular Weight: 150 kDa

Gene ID: 2160

UniProt: P03951