MESDC2 antibody (AA 80-205)

Catalog No. ABIN7602508

The Rabbit Polyclonal anti-MESDC2 antibody has been validated for WB, ELISA and FACS. It is suitable to detect MESDC2 in samples from Human.

Quick Overview for MESDC2 antibody (AA 80-205) (ABIN7602508)

Target: MESDC2 (Mesoderm Development Candidate 2 (MESDC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MESDC2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-MESDC2 Antibody

Binding Specificity: AA 80-205

Purpose: Anti-MESDC2/MESD Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-MESDC2/MESD Antibody Picoband® (ABIN7602508). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MESDC2/MESD recombinant protein (Position: D80-Q205).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Culi, J., Mann, R. S. Boca, an endoplasmic reticulum protein required for Wingless signaling and trafficking of LDL receptor family members in Drosophila. Cell 112: 343-354, 2003. 2. Gross, M. B. Personal Communication. Baltimore, Md. 10/15/2019. 3. Hsieh, J.-C., Lee, L., Zhang, L., Wefer, S., Brown, K., DeRossi, C., Wines, M. E., Rosenquist, T., Holdener, B. C. Mesd encodes the LRP5/6 chaperone essential for specification of mouse embryonic polarity. Cell 112: 355-367, 2003.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for MESDC2

Target: MESDC2 (Mesoderm Development Candidate 2 (MESDC2))

Alternative Name: MESD

Background:

Synonyms: Protein Bop, BH3-only protein, Retrotransposon Gag-like protein 10, RTL10, BOP, C22orf29

Tissue Specificity: Ubiquitously expressed.

Background: Mesoderm development candidate genes 1 (MESDC1) and 2 (MESDC2) were identified from the mesoderm development (MESD) deletion interval located on mouse chromosome 7. MESD acts as a chaperone for low-density lipoprotein receptor (LDLR) proteins in the ER, and particularly associates with Wnt signaling pathway coreceptors LRP5 and LPR6. MESD is required for proper LRP5/6 folding and maturation to the cell surface, which plays a major role in Wnt signaling. The interaction between MESD and LRP5 is disrupted by a G171V mutation in LRP5 that is found in individuals with a familial phenotype characterized by high bone mass.

Molecular Weight: 24 kDa

Gene ID: 23184

UniProt: Q14696