DBN1 antibody (AA 9-649)

Catalog No. ABIN7602637

The Mouse Monoclonal anti-DBN1 antibody has been validated for WB, IHC and FACS. It is suitable to detect DBN1 in samples from Human, Mouse, Rat and Monkey.

Quick Overview for DBN1 antibody (AA 9-649) (ABIN7602637)

Target: DBN1 (Drebrin 1 (DBN1))

Reactivity: Human, Mouse, Rat, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This DBN1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 4F6E7

Product Details anti-DBN1 Antibody

Binding Specificity: AA 9-649

Purpose: Anti-Drebrin/DBN1 Antibody Picoband® (monoclonal, 4F6E7)

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Drebrin/DBN1 Antibody Picoband® (monoclonal, 4F6E7) (ABIN7602637). Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Drebrin/DBN1 recombinant protein (Position: H9-D649).

Isotype: IgG2a

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat, Monkey
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
1. Akbar, M., Kim, H. Y. Protective effects of docosahexaenoic acid in staurosporine-induced apoptosis: involvement of phosphatidylinositol-3 kinase pathway. J. Neurochem. 82: 655-665, 2. Calon, F., Lim, G. P., Yang, F., Morihara, T., Teter, B., Ubeda, O., Rostaing, P., Triller, A., Salem, N., Jr., Ashe, K. H., Frautschy, S. A., Cole, G. M. Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron 43: 633-645, 2004. 3. Harigaya, Y., Shoji, M., Shirao, T., Hirai, S. Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease. J. Neurosci. Res. 43: 87-92, 1996.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for DBN1

Target: DBN1 (Drebrin 1 (DBN1))

Alternative Name: DBN1

Background:

Synonyms: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial, Cytochrome c oxidase polypeptide IV, Cytochrome c oxidase subunit IV isoform 1, COX IV-1, COX4I1, COX4

Tissue Specificity: Highly expressed in liver. Expressed in testis and weakly in colon.

Background: Drebrin is a protein that in humans is encoded by the DBN1 gene. The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.

Molecular Weight: 120 kDa

Gene ID: 1627

UniProt: Q16643

Pathways: Maintenance of Protein Location