OAS3 antibody (AA 990-1087)

Catalog No. ABIN7602725

This anti-OAS3 antibody is a Rabbit Polyclonal antibody detecting OAS3 in WB, ELISA, IF, ICC and FACS. Suitable for Human.

Quick Overview for OAS3 antibody (AA 990-1087) (ABIN7602725)

Target: OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OAS3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Product Details anti-OAS3 Antibody

Binding Specificity: AA 990-1087

Purpose: Anti-OAS3 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-OAS3 Antibody Picoband® (ABIN7602725). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human OAS3 recombinant protein (Position: N990-V1087).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.25 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Hovanessian, A. G., Laurent, A. G., Chebath, J., Galabru, J., Robert, N., Svab, J. Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies. EMBO J. 6: 1273-1280, 1987. 2. Hovnanian, A., Rebouillat, D., Mattei, M.-G., Levy, E. R., Marie, I., Monaco, A. P., Hovanessian, A. G. The human 2-prime,5-prime-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40- kDa forms. Genomics 52: 267-277, 1998. 3. Lin, R.-J., Yu, H.-P., Chang, W.-C., Liao, C.-L., Lin, Y.-L. Distinct antiviral roles for human 2-prime,5-prime-oligoadenylate synthetase family members against Dengue virus infection. J. Immun. 183: 8035-8043, 2009.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for OAS3

Target: OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))

Alternative Name: OAS3

Background:

Synonyms: 2'-5'-oligoadenylate synthase 3, (2-5')oligo (A) synthase 3, 2-5A synthase 3, p100 OAS, p100OAS, OAS3, P/OKcl.4

Tissue Specificity: Present at high level in placenta trophoblast.

Background: 2'-5'-oligoadenylate synthetase 3 is an enzyme that in humans is encoded by the OAS3 gene. It is mapped to 12q24.13. This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance.

Molecular Weight: 123 kDa

Gene ID: 4940

UniProt: Q9Y6K5

Pathways: Hepatitis C