ADRB1 antibody (C-Term)

Catalog No. ABIN7602843

This Rabbit Polyclonal antibody specifically detects ADRB1 in WB. It exhibits reactivity toward Rat and Mouse.

Quick Overview for ADRB1 antibody (C-Term) (ABIN7602843)

Target: ADRB1 (Adrenergic, beta-1-, Receptor (ADRB1))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRB1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ADRB1 Antibody

Binding Specificity: C-Term

Purpose: Anti-ADRB1 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-ADRB1 Antibody Picoband® (ABIN7602843). Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human ADRB1, which shares 81.2% amino acid (aa) sequence identity with mouse and rat ADRB1.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
1. Bachman, E. S., Dhillon, H., Zhang, C.-Y., Cinti, S., Bianco, A. C., Kobilka, B. K., Lowell, B. B. Beta-AR signaling required for diet-induced thermogenesis and obesity resistance. Science 297: 843-845, 2002. 2. Cagliani, R., Fumagalli, M., Pozzoli, U., Riva, S., Comi, G. P., Torri, F., Macciardi, F., Bresolin, N., Sironi, M. Diverse evolutionary histories for beta-adrenoreceptor genes in humans. Am. J. Hum. Genet. 85: 64-75, 2009. 3. Dionne, I. J., Garant, M. J., Nolan, A. A., Pollin, T. I., Lewis, D. G., Shuldiner, A. R., Poehlman, E. T. Association between obesity and a polymorphism in the beta-1-adrenoceptor gene (gly389arg ADRB1) in Caucasian women. Int. J. Obes. Relat. Metab. Disord. 26: 633-639, 2002.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for ADRB1

Target: ADRB1 (Adrenergic, beta-1-, Receptor (ADRB1))

Alternative Name: ADRB1

Background:

Synonyms: Serine/threonine-protein kinase Sgk1, Serum/glucocorticoid-regulated kinase 1, SGK1, SGK

Tissue Specificity: Expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney and lung. Isoform 2 is strongly expressed in brain and pancreas, weaker in heart, placenta, lung, liver and skeletal muscle.

Background: The beta-1 adrenergic receptor (β1 adrenoceptor), also known as ADRB1, is a beta-adrenergic receptor, and also denotes the human gene encoding it. The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Beta-1 adrenoceptors are predominately located in the heart. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure.

Molecular Weight: 51 kDa

Gene ID: 153

UniProt: P08588

Pathways: cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Brown Fat Cell Differentiation