OLIG2 antibody (C-Term)

Catalog No. ABIN7602906

This Rabbit Polyclonal antibody specifically detects OLIG2 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for OLIG2 antibody (C-Term) (ABIN7602906)

Target: OLIG2 (Oligodendrocyte Lineage Transcription Factor 2 (OLIG2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OLIG2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-OLIG2 Antibody

Binding Specificity: C-Term

Purpose: Anti-OLIG2 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-OLIG2 Antibody Picoband® (ABIN7602906). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human OLIG2, which shares 95% amino acid (aa) sequence identity with mouse OLIG2.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
1. Buffo, A., Vosko, M. R., Erturk, D., Hamann, G. F., Jucker, M., Rowitch, D., Gotz, M. Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair. Proc. Nat. Acad. Sci. 102: 18183-18188, 2005. 2. Georgieva, L., Moskvina, V., Peirce, T., Norton, N., Bray, N. J., Jones, L., Holmans, P., MacGregor, S., Zammit, S., Wilkinson, J., Williams, H., Nikolov, I., and 9 others. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Proc. Nat. Acad. Sci. 103: 12469-12474, 2006. 3. Huang, K., Tang, W., Tang, R., Xu, Z., He, Z., Li, Z., Xu, Y., Li, X., He, G., Feng, G., He, L., Shi, Y. Positive association between OLIG2 and schizophrenia in the Chinese Han population. Hum. Genet. 122: 659-660, 2008.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for OLIG2

Target: OLIG2 (Oligodendrocyte Lineage Transcription Factor 2 (OLIG2))

Alternative Name: OLIG2

Background:

Synonyms: Solute carrier family 2, facilitated glucose transporter member 9, Glucose transporter type 9, GLUT-9, Urate transporter, SLC2A9, GLUT9

Tissue Specificity: Most strongly expressed in basolateral membranes of proximal renal tubular cells, liver and placenta. Also detected in lung, blood leukocytes, heart skeletal muscle and chondrocytes from articular cartilage. Isoform 2 is only detected in the apical membranes of polarized renal tubular cells and placenta. Isoform 1 and isoform 2 are detected in kidney membrane (at protein level).

Background: Oligodendrocyte transcription factor (OLIG2) is a basic helix-loop-helix (bHLH) transcription factor encoded by the Olig2 gene. This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14,21)(q11.2,q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome

Molecular Weight: 40 kDa

Gene ID: 10215

UniProt: Q13516