TAL1 antibody (C-Term)

Catalog No. ABIN7602930

This Rabbit Polyclonal antibody specifically detects TAL1 in WB and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TAL1 antibody (C-Term) (ABIN7602930)

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAL1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-TAL1 Antibody

Binding Specificity: C-Term

Purpose: Anti-TAL1 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-TAL1 Antibody Picoband® (ABIN7602930). Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human TAL1, which shares 82.4% amino acid (aa) sequence identity with mouse and rat TAL1.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
1. Hosur, V., Cox, M. L., Burzenski, L. M., Riding, R. L., Alley, L., Lyons, B. L., Kavirayani, A., Martin, K. A., Cox, G. A., Johnson, K. R., Shultz, L. D. Retrotransposon insertion in the T-cell acute lymphocytic leukemia 1 (Tal1) gene is associated with severe renal disease and patchy alopecia in hairpatches (Hpt) mice. PLoS One 8: e53426, 2013. Note: Electronic Article. 2. Hu, X., Li, X., Valverde, K., Fu, X., Noguchi, C., Qiu, Y., Huang, S. LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc. Nat. Acad. Sci. 106: 10141-10146, 2009.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for TAL1

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Alternative Name: TAL1

Background:

Synonyms: T-cell acute lymphocytic leukemia protein 1, TAL-1, Class A basic helix-loop-helix protein 17, bHLHa17, Stem cell protein, T-cell leukemia/lymphoma protein 5, TAL1, BHLHA17, SCL, TCL5

Tissue Specificity: Leukemic stem cell.

Background: T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene. The protein encoded by TAL1 is a basic helix-loop-helix transcription factor. TAL1 is a transcriptionally complex gene that is expressed throughout development, activating or repressing transcription in hematopoietic, neural, and endothelial precursors. This gene is mapped to chromosome 1p33.

Molecular Weight: 40-45 kDa

Gene ID: 6886

UniProt: P17542

Pathways: Stem Cell Maintenance