DPYSL2 antibody (N-Term)

Catalog No. ABIN7603208

This anti-DPYSL2 antibody is a Rabbit Polyclonal antibody detecting DPYSL2 in WB, IF and ICC. Suitable for Human, Mouse and Rat.

Quick Overview for DPYSL2 antibody (N-Term) (ABIN7603208)

Target: DPYSL2 (Dihydropyrimidinase-Like 2 (DPYSL2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DPYSL2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-DPYSL2 Antibody

Binding Specificity: N-Term

Purpose: Anti-CRMP2/DPYSL2 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-CRMP2/DPYSL2 Antibody Picoband® (ABIN7603208). Tested in IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human CRMP2/DPYSL2, which shares 94.1% amino acid (aa) sequence identity with both mouse and rat CRMP2/DPYSL2.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
1. Abe, H., Jitsuki, S., Nakajima, W., Murata, Y., Jitsuki-Takahashi, A., Katsuno, Y., Tada, H., Sano, A., Suyama, K., Mochizuki, N., Komori, T., Masuyama, H., Okuda, T., Goshima, Y., Higo, N., Takahashi, T. CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage. Science 360: 50-57, 2018. 2. Brittain, J. M., Duarte, D. B., Wilson, S. M., Zhu, W., Ballard, C., Johnson, P. L., Liu, N., Xiong, W., Ripsch, M. S., Wang, Y., Fehrenbacher, J. C., Fitz, S. D., and 20 others. Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca(2+) channel complex. Nature Med. 17: 822-829, 2011. 3. Fukata, Y., Itoh, T. J., Kimura, T., Menager, C., Nishimura, T., Shiromizu, T., Watanabe, H., Inagaki, N., Iwamatsu, A., Hotani, H., Kaibuchi, K. CRMP-2 binds to tubulin heterodimers to promote microtubule assembly. Nature Cell Biol. 4: 583-591, 2002.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for DPYSL2

Target: DPYSL2 (Dihydropyrimidinase-Like 2 (DPYSL2))

Alternative Name: DPYSL2

Background:

Synonyms: Talin-1, TLN1, KIAA1027, TLN

Tissue Specificity: Placenta and skin. Predominantly expressed in mammary gland tissue.

Background: Dihydropyrimidinase-related protein 2 is an enzyme that in humans is encoded by the DPYSL2 gene. This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Molecular Weight: 65 kDa

Gene ID: 1808

UniProt: Q16555

Pathways: Regulation of Cell Size