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TGFB1 antibody (N-Term)

This anti-TGFB1 antibody is a Rabbit Polyclonal antibody detecting TGFB1 in IHC. Suitable for Rat.
Catalog No. ABIN7603238

Quick Overview for TGFB1 antibody (N-Term) (ABIN7603238)

Target

See all TGFB1 Antibodies
TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Reactivity

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Rat

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This TGFB1 antibody is un-conjugated

Application

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Immunohistochemistry (IHC)
  • Binding Specificity

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    N-Term

    Purpose

    Anti-TGF beta 1/TGFB1 Antibody

    Cross-Reactivity (Details)

    No cross-reactivity with other proteins.

    Characteristics

    Anti-TGF beta 1/TGFB1 Antibody Picoband® (ABIN7603238). Tested in IHC applications. This antibody reacts with Rat.

    Purification

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the N-terminus of human TGF beta 1/TGFB1, identical to the related mouse and rat sequences.

    Isotype

    IgG
  • Application Notes

    Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Rat
    1. Awad, M. R., El-Gamel, A., Hasleton, P., Turner, D. M., Sinnott, P. J., Hutchinson, I. V. Genotypic variation in the transforming growth factor-beta-1 gene: association with transforming growth factor-beta-1 production, fibrotic lung disease, and graft fibrosis after lung transplantation. Transplantation 66: 1014-1020, 1998. 2. Azar, S. T., Salti, I., Zantout, M. S., Major, S. Alterations in plasma transforming growth factor beta in normoalbuminuric type 1 and type 2 diabetic patients. J. Clin. Endocr. Metab. 85: 4680-4682, 2000. 3. Bernasconi, P., Torchiana, E., Confalonieri, P., Brugnoni, R., Barresi, R., Mora, M., Conelio, F., Morandi, L., Mantegazza, R. Expression of transforming growth factor-beta-1 in dystrophic patient muscles correlates with fibrosis: pathogenetic role of a fibrogenic cytokine. J. Clin. Invest. 96: 1137-1144, 1995.

    Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Concentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Storage

    4 °C,-20 °C

    Storage Comment

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

    Alternative Name

    TGFB1

    Background

    Synonyms: NAD-dependent protein deacetylase sirtuin-1, hSIRT1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, hSIR2, SirtT1 75 kDa fragment, 75SirT1, SIRT1, SIR2L1

    Tissue Specificity: Widely expressed.

    Background: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.

    Molecular Weight

    120 kDa

    Gene ID

    7040

    UniProt

    P01137

    Pathways

    EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy, Cancer Immune Checkpoints
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