ITK antibody

Catalog No. ABIN7605326

This anti-ITK antibody is a Rabbit Monoclonal antibody detecting ITK in WB, IHC and FACS. Suitable for Human.

Quick Overview for ITK antibody (ABIN7605326)

Target: ITK (IL2-Inducible T-Cell Kinase (ITK))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ITK antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: ACAB-9

Product Details anti-ITK Antibody

Purpose: Anti-ITK Monoclonal Antibody

Characteristics: Anti-ITK Monoclonal Antibody (ABIN7605326). Tested in WB, IHC, Flow Cytometry applications. This antibody reacts with Human.

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human ITK.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000
IHC 1:50-1:200
FC 1:60

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Concentration: Lot specific

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Target Details for ITK

Target: ITK (IL2-Inducible T-Cell Kinase (ITK))

Alternative Name: ITK

Background:

Synonyms: Interferon-induced, double-stranded RNA-activated protein kinase,2.7.11.1,Eukaryotic translation initiation factor 2-alpha kinase 2,eIF-2A protein kinase 2,Interferon-inducible RNA-dependent protein kinase,P1/eIF-2A protein kinase,Protein kinase RNA-activated,PKR,Protein kinase R ,Tyrosine-protein kinase EIF2AK2,2.7.10.2,p68 kinase,EIF2AK2,PKR, PRKR,

Tissue Specificity: Highly expressed in thymus, spleen and bone marrow compared to non-hematopoietic tissues such as small intestine, liver, or kidney tissues. Colocalizes with GSK3B and TAU in the Alzheimer disease (AD) brain. Elevated levels seen in breast and colon carcinomas,and which correlates with tumor progression and invasiveness or risk of progression. .

Molecular Weight: 37 kDa

UniProt: Q08881

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway