Calreticulin antibody

Catalog No. ABIN7607951

The Rabbit Monoclonal anti-Calreticulin antibody has been validated for ELISA. It is suitable to detect Calreticulin in samples from Human.

Quick Overview for Calreticulin antibody (ABIN7607951)

Target: Calreticulin (CALR)

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Calreticulin antibody is un-conjugated

Application: ELISA

Clone: 1A8

Product Details anti-Calreticulin Antibody

Purpose: Anti-CALR antibody(1A8), Rabbit mAb

Purification: Purified from cell culture supernatant by affinity chromatography

Application Details

Application Notes: ELISA 1/5000-10000

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details for Calreticulin

Target: Calreticulin (CALR)

Alternative Name: CALR

Background: Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.[provided by RefSeq, May 2020]

UniProt: P27797

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response