Dopamine d2 Receptor antibody (AA 201-300)

Catalog No. ABIN730858

This Rabbit Polyclonal antibody specifically detects Dopamine d2 Receptor in WB, ELISA, IF (cc), IF (p), IHC (p) and IHC (fro). It exhibits reactivity toward Human, Rat and Mouse and has been mentioned in 8+ publications.

Quick Overview for Dopamine d2 Receptor antibody (AA 201-300) (ABIN730858)

Target: Dopamine d2 Receptor (DRD2) (Dopamine Receptor D2 (DRD2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dopamine d2 Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Dopamine d2 Receptor Antibody

Binding Specificity: AA 201-300

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DRD2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-Dopamine d2 Receptor antibody (ABIN730858)

Qian, Cai, Wang, Zhang, Zhao, Qian, Yang, Liu, Hasegawa: "Effect of Gingerol on Cisplatin-Induced Pica Analogous to Emesis Via Modulating Expressions of Dopamine 2 Receptor, Dopamine Transporter and Tyrosine Hydroxylase in the Vomiting Model of Rats." in: Yonago acta medica, Vol. 59, Issue 2, pp. 100-10, (2016) (PubMed).

Yano, Hide, Uekawa, Honda, Mikami, Kuratsu: "Mixed Pituitary Gangliocytoma and Prolactinoma Resistant to the Cabergoline Treatment." in: World neurosurgery, Vol. 95, pp. 620.e17-620.e22, (2016) (PubMed).

Zhang, Zhang, Zhang, Meng, Jia, Zhang, Bu, Zhu, Ma, Ye, Zhang, Ren, Sun, Tang: "Moderate swimming suppressed the growth and metastasis of the transplanted liver cancer in mice model: with reference to nervous system." in: Oncogene, Vol. 35, Issue 31, pp. 4122-31, (2016) (PubMed).

Mao, Yu, Hu, Hu: "Dopamine D2 receptor blocker thioridazine induces cell death in human uterine cervical carcinoma cell line SiHa." in: The journal of obstetrics and gynaecology research, Vol. 41, Issue 8, pp. 1240-5, (2015) (PubMed).

Salgado, López-Doval, Pereiro, Lafuente: "Perfluorooctane sulfonate (PFOS) exposure could modify the dopaminergic system in several limbic brain regions." in: Toxicology letters, Vol. 240, Issue 1, pp. 226-35, (2015) (PubMed).

Hu, Liu, Qiao: "Increased extracellular dopamine and 5-hydroxytryptamine levels contribute to enhanced subthalamic nucleus neural activity during exhausting exercise." in: Biology of sport, Vol. 32, Issue 3, pp. 187-92, (2015) (PubMed).

Xu, Wang, Chen, Chen, Li, Shao, Li, Lu, Zhou: "Dopamine D1 receptor activation induces dehydroepiandrosterone sulfotransferase (SULT2A1) in HepG2 cells." in: Acta pharmacologica Sinica, Vol. 35, Issue 7, pp. 889-98, (2014) (PubMed).

Target Details for Dopamine d2 Receptor

Target: Dopamine d2 Receptor (DRD2) (Dopamine Receptor D2 (DRD2))

Alternative Name: DRD2

Background:

Synonyms: D2R, D2DR, D(2) dopamine receptor, Dopamine D2 receptor, DRD2

Background: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.

Gene ID: 1813

UniProt: P14416

Pathways: Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Inositol Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity