APCS antibody (AA 143-223) (CF®647)

Catalog No. ABIN7649436

This anti-APCS antibody is a Mouse Monoclonal antibody detecting APCS in IHC and IHC (fp). Suitable for Human.

Quick Overview for APCS antibody (AA 143-223) (CF®647) (ABIN7649436)

Target: APCS (Amyloid P Component, Serum (APCS))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This APCS antibody is conjugated to CF®647

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: APCS-3240

Product Details anti-APCS Antibody (CF®647)

Binding Specificity: AA 143-223

Purpose: Serum Amyloid P / APCS(APCS/3240), CF647 conjugate

Characteristics: Serum amyloid P (SAP) is a glycoprotein belonging to the pentraxin family of proteins, which has a characteristic pentameric organization and calciumdependent ligand binding. Secreted by liver epithelial cells, SAP is found in serum and urine. Although the function of SAP has not been clearly established, it has been shown to interact with DNA and histones and is thought to play a role in scavenging nuclear material released from damaged circulating cells. Also designated PTX2, SAP is a precursor of the protein amyloid P component (AP), which is universally associated with the amyloid deposits in all forms of amyloidoses, including Alzheimer's disease. SAP is a decamer of ten identical, noncovalently linked subunits, each of which may be post-translationally modified by glycosylation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant fragment of human APCS protein (around aa 143-223)

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: Human endometrial carcinoma tissue (IHC).

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for APCS

Target: APCS (Amyloid P Component, Serum (APCS))

Alternative Name: APCS

Background:

Synonyms: 9.5S alpha 1 glycoprotein, Amyloid P component serum (APCS), Pentaxin related, Pentraxin 2 (PTX2), Serum Amyloid P (SAP), Serum amyloid P component

Gene Symbol: APCS

Molecular Weight: 200 kDa (oligomeric), 26 kDa (non-covalently bound subunit), 30 kDa (glycosylated SAP subunit)

Gene ID: 325

UniProt: P02743