Liver Arginase antibody (AA 11-97) (CF®405S)

Catalog No. ABIN7649657

The Mouse Monoclonal anti-Liver Arginase antibody has been validated for IHC and IHC (fp). It is suitable to detect Liver Arginase in samples from Human.

Quick Overview for Liver Arginase antibody (AA 11-97) (CF®405S) (ABIN7649657)

Target: Liver Arginase (ARG1) (Arginase, Liver (ARG1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Liver Arginase antibody is conjugated to CF®405S

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: ARG1-1125 ARG1-1126

Product Details anti-Liver Arginase Antibody (CF®405S)

Binding Specificity: AA 11-97

Purpose: Arginase 1 (Hepatocellular Carcinoma Marker)(ARG1/1125+ ARG1/1126), CF405S conjugate

Characteristics: This antibody recognizes a protein of 35-38 kDa, which is identified as Arginase 1 (ARG1). Arginase is a manganese metallo-enzyme that catalyzes the hydrolysis of arginine to generate ornithine and urea. Arginase I and II are isoenzymes which differ in subcellular localization, regulation, and possibly function. Arginase I is a cytosolic enzyme, which is expressed mainly in the liver as part of the urea cycle, whereas arginase II is a mitochondrial protein found in a variety of tissues. Antibodies to Arginase 1 label hepatocytes in normal tissues and granulocytes in peripheral blood. Arginase 1 is a sensitive and specific marker for identification of hepatocellular carcinoma.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant human ARG1 protein fragment (around aa11-97)

Isotype: IgG3, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: 293T cells. Hepatocellular Carcinoma (HCC).

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for Liver Arginase

Target: Liver Arginase (ARG1) (Arginase, Liver (ARG1))

Alternative Name: Arginase 1

Background:

Synonyms: Arginase 1, ARG1, liver-type arginase, type I arginase

Gene Symbol: ARG1

Tissue Expression: Liver

Molecular Weight: 35-38 kDa

Gene ID: 383

UniProt: P05089

Pathways: Cellular Response to Molecule of Bacterial Origin