DBN1 antibody (AA 150-281) (CF®405S)

Catalog No. ABIN7653272

The Mouse Monoclonal anti-DBN1 antibody has been validated for WB, IHC and IHC (fp). It is suitable to detect DBN1 in samples from Human.

Quick Overview for DBN1 antibody (AA 150-281) (CF®405S) (ABIN7653272)

Target: DBN1 (Drebrin 1 (DBN1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DBN1 antibody is conjugated to CF®405S

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: DBN1-2879

Product Details anti-DBN1 Antibody (CF®405S)

Binding Specificity: AA 150-281

Purpose: Drebrin 1 (DBN1)(DBN1/2879), CF405S conjugate

Characteristics: Drebrins (developmentally regulated brain proteins) are cytoplasmic proteins that bind F-actin in the brain and are involved in cell migration, extension of neuronal processes and plasticity of dendrites. There are three isoforms: two embryonic types (E1 and E2), and an adult type (A), generated by alternative RNA splicing from a single Drebrin gene. Drebrins are expressed mainly in brain neurons but are also found in skeletal muscle, heart, placenta, pancreas and kidney. Drebrin has been designated as a marker of the dendritic spine. Decreases in Drebrin levels in the brain have been been associated with Alzheimer's disease and Down syndrome. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant fragment (aa 150-281) of human DBN1 protein

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for DBN1

Target: DBN1 (Drebrin 1 (DBN1))

Alternative Name: Drebrin 1

Background:

Synonyms: Developmentally regulated brain protein, Drebrin 1, Drebrin, Drebrin E, Drebrin E2, Drebrin1, DrebrinE

Gene Symbol: DBN1

Tissue Expression: Heart|Skeletal Muscle|Brain|Kidney|Neurons|Pancreas|Placenta

Molecular Weight: 120 kDa

Gene ID: 1627

UniProt: Q16643

Pathways: Maintenance of Protein Location