CD59 antibody (AA 52-100) (HRP)

Catalog No. ABIN732347

The Rabbit Polyclonal anti-CD59 antibody has been validated for ELISA, IHC (p) and IHC (fro). It is suitable to detect CD59 in samples from Human.

Quick Overview for CD59 antibody (AA 52-100) (HRP) (ABIN732347)

Target: CD59

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD59 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CD59 Antibody (HRP)

Binding Specificity: AA 52-100

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CD59

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CD59

Target: CD59

Alternative Name: CD59

Background:

Synonyms: 1F5, EJ16, EJ3, EL32, G344, MIN1, MIN2, MIN3, MIRL, HRF2, MACIF, MEM43, MIC11, MSK21, 16.3A5, HRF-2, MAC-IP, p18-2, CD59 glycoprotein, 1F5 antigen, 2 kDa homologous restriction factor, MAC-inhibitory protein, MEM43 antigen, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, Protectin, CD59

Background: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.

Gene ID: 966

UniProt: P13987

Pathways: Complement System