FcRn antibody (AA 24-215) (Biotin)

Catalog No. ABIN7657762

This Mouse Monoclonal antibody specifically detects FcRn in IHC and IHC (fp). It exhibits reactivity toward Human.

Quick Overview for FcRn antibody (AA 24-215) (Biotin) (ABIN7657762)

Target: FcRn (neonatal Fc Receptor (FcRn))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FcRn antibody is conjugated to Biotin

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: FCGRT-2932

Product Details anti-FcRn Antibody (Biotin)

Binding Specificity: AA 24-215

Purpose: FCGRT / FcRn (IgG Transporter)(FCGRT/2932), Biotin conjugate

Characteristics: This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. FCGRT is present in the intestinal epithelium of neonates and mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn to acquire passive immunity. FCGRT is comprised of a heavy chain and -2-Microglobulin. FCGRT localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal degradation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant fragment of human FCGRT protein (around aa 24-215)

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: THP1 or HepG2 cells. Cerebellum or Testis.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for FcRn

Target: FcRn (neonatal Fc Receptor (FcRn))

Alternative Name: FCGRT

Background:

Synonyms: Fc fragment of IgG, receptor transporter, alpha, FCGRT, FCRN, alpha chain, IgG Fc fragment receptor transporter alpha chain, IgG Gc receptor, IgG receptor FcRn large subunit p51, Immunoglobulin receptor, intestinal, heavy chain, Neonatal Fc receptor

Gene Symbol: FCGRT

Molecular Weight: 46 kDa

Gene ID: 2217

UniProt: P55899

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process