Synaptophysin antibody (AA 224-313) (CF®405S)

Catalog No. ABIN7660484

The Mouse Monoclonal anti-Synaptophysin antibody has been validated for IHC and IHC (fp). It is suitable to detect Synaptophysin in samples from Human.

Quick Overview for Synaptophysin antibody (AA 224-313) (CF®405S) (ABIN7660484)

Target: Synaptophysin (SYP)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Synaptophysin antibody is conjugated to CF®405S

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: SYP-3551

Product Details anti-Synaptophysin Antibody (CF®405S)

Binding Specificity: AA 224-313

Purpose: Synaptophysin (Neuroendocrine Marker)(SYP/3551), CF405S conjugate

Characteristics: This monospecific monoclonal antibody recognizes a protein of 38 kDa that is identified as synaptophysin. It is an N-glycosylated integral membrane protein found in neurons and endocrine cells. Synaptophysin contains four transmembrane domains and may function as a gap junction-like channel. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse, finely granular, cytoplasmic staining is observed, which probably correlates with the distribution of the antigen within neurosecretory vesicles. Synaptophysin is an independent, broad-range marker of neural and neuroendocrine differentiation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant fragment (around aa 224-313) of human Synaptophysin (SYP) protein

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: HepG2, SH-SY-5Y, HeLa or Y79 cells. Pancreas, Cerebellum or Pheochromocytoma.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for Synaptophysin

Target: Synaptophysin (SYP)

Alternative Name: Synaptophysin

Background:

Synonyms: Major synaptic vesicle protein p38, MRX96, MRXSYP, Syn p38, Syp, SYPH

Gene Symbol: MSH2

Molecular Weight: 38 kDa

Gene ID: 6855

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity