VTCN1 antibody (Biotin)

Catalog No. ABIN7661789

The Mouse Monoclonal anti-VTCN1 antibody is suitable to detect VTCN1 in samples from Human. It has been validated for WB, IHC, FACS, IHC (fp) and IF.

Quick Overview for VTCN1 antibody (Biotin) (ABIN7661789)

Target: VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This VTCN1 antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)), Immunofluorescence (IF)

Clone: B7H4-1788

Product Details anti-VTCN1 Antibody (Biotin)

Purpose: B7-H4 (Immuno-Inhibitory Protein)(B7H4/1788), Biotin conjugate

Characteristics: B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: A recombinant fragment of human B7-H4 protein

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: HCT116, HeLa, SKBr-3, MCF-7 cells. Ovary, Pancreas, Placenta or Spleen.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for VTCN1

Target: VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))

Alternative Name: B7-H4

Background:

Synonyms: B7-H4, B7H4, B7X, B7 family member, H4, B7 homolog 4, B7 superfamily member 1, B7S1, B7 family member H4

Gene Symbol: VTCN1

Molecular Weight: 35 kDa

Gene ID: 79679

UniProt: Q7Z7D3