CD27 antibody

Catalog No. ABIN7670002

The Mouse Monoclonal anti-CD27 antibody is suitable to detect CD27 in samples from Human. It has been validated for FACS.

Quick Overview for CD27 antibody (ABIN7670002)

Target: CD27 (CD27 Molecule (CD27))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD27 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: O323

Product Details anti-CD27 Antibody

Purpose: Purified Anti-Human CD27 Antibody[O323]

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: ≥ 1 mg/mL

Buffer: Phosphate buffered solution, pH 7.2, containing 0.05 % proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: avoid freeze / thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for CD27

Target: CD27 (CD27 Molecule (CD27))

Alternative Name: CD27

Background: S152. LPFS,T-cell activation antigen CD,TNFRSF,S152.LPFS,CD27,S152,S152. LPFS2,T14,TNFRSF7,Tp55,S152.LPFS2,CD27L receptor,T-cell activation antigen CD27, S152, TNFRSF7,CD 27,CD27 antigen,CD27 Molecule,LPFS2,MGC20393,OTTHUMP00000238557,T cell activation antigen CD27,T cell antivation antigen S152,TNFRSF 7,TNFSF7,Tp 55,Tumor necrosis factor receptor superfamily member 7,The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.

UniProt: P26842

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints