CTLA4 antibody

Catalog No. ABIN7670048

This anti-CTLA4 antibody is a Mouse Monoclonal antibody detecting CTLA4 in FACS. Suitable for Human.

Quick Overview for CTLA4 antibody (ABIN7670048)

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CTLA4 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: BNI3

Product Details anti-CTLA4 Antibody

Purpose: Purified Anti-Human CD152 Antibody[BNI3]

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: ≥ 1 mg/mL

Buffer: Phosphate buffered solution, pH 7.2, containing 0.05 % proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: avoid freeze / thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for CTLA4

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Alternative Name: CD152

Background: GRD,ALPS,IDDM,Cytotoxic T-lymphocyte protein,Cytotoxic T-lymphocyte-associated antigen,Cytotoxic T-Lymphocyte-Associated Protein,CELIAC,CTLA4,ALPS5,CD,CD152,CELIAC3,CTLA-4,GRD4,GSE,IDDM12,Cytotoxic T-lymphocyte protein 4,Cytotoxic T-lymphocyte-associated antigen 4,Cytotoxic T-Lymphocyte-Associated Protein 4,This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

UniProt: P16410

Pathways: Cancer Immune Checkpoints