MCAM antibody

Catalog No. ABIN7670102

This anti-MCAM antibody is a Mouse Monoclonal antibody detecting MCAM in FACS. Suitable for Human.

Quick Overview for MCAM antibody (ABIN7670102)

Target: MCAM (Melanoma Cell Adhesion Molecule (MCAM))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MCAM antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: AA98

Product Details anti-MCAM Antibody

Purpose: Purified Anti-Human CD146 Antibody[AA98]

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: ≥ 1 mg/mL

Buffer: Phosphate buffered solution, pH 7.2, containing 0.05 % proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: avoid freeze / thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for MCAM

Target: MCAM (Melanoma Cell Adhesion Molecule (MCAM))

Alternative Name: CD146

Background: MUC,cell surface glycoprotein MUC,MCAM,CD146,MUC18,cell surface glycoprotein MUC18, S-endo, MCAM, Mel-CAM, Endo-CAM,CD146,cell surface glycoprotein MUC18,MUC18,A32 antigen,CD 146,CD146 antigen,Cell surface glycoprotein P1H12,Gicerin,Melanoma adhesion molecule,Melanoma associated antigen A32,Melanoma associated antigen MUC18,Melanoma associated glycoprotein MUC18,melanoma cell adhesion molecule,Melanoma-associated antigen A32,Melanoma-associated antigen MUC18,MelCAM,MUC 18,S endo 1,S endo 1 endothelial associated antigen,S-endo 1 endothelial-associated antigen,Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

UniProt: P43121