HLA DQ antibody (PE,Cy5.5)

Catalog No. ABIN7670251

The Mouse Monoclonal anti-HLA DQ antibody has been validated for FACS. It is suitable to detect HLA DQ in samples from Human.

Quick Overview for HLA DQ antibody (PE,Cy5.5) (ABIN7670251)

Target: HLA DQ (HLA-DQ) (MHC Class II HLA-DQ (HLA-DQ))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HLA DQ antibody is conjugated to PE,Cy5.5

Application: Flow Cytometry (FACS)

Clone: 1a3

Product Details anti-HLA DQ Antibody (PE,Cy5.5)

Purpose: PE/Cyanine5.5 Anti-Human HLA-DQ Antibody[1a3]

Immunogen: E-AB-F09802I

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 5 μL/tests

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09 % stabilizer and 1 % protein protectant

Handling Advice: Please protected from prolonged exposure to light and do not freeze.

Storage: 4 °C

Storage Comment: This product can be stored at 2-8°C for 12 months.

Expiry Date: 12 months

Target Details for HLA DQ

Target: HLA DQ (HLA-DQ) (MHC Class II HLA-DQ (HLA-DQ))

Alternative Name: HLA-DQ

Background: MHC class II DQ monomorphic antigen,MHC II,HLA-DQ is also known as MHC class II DQ monomorphic antigen. The major histocompatibility complex is composed of two heterodimeric glycoproteins (α and β chains) with apparent molecular weights of 27 and 32 kD. In contrast to other MHC class II molecules, both polypeptide chains of HLA-DQ are polymorphic, with the α chain showing an extremely high degree of polymorphism. HLA-DQ is expressed on B cells in the peripheral blood, and weakly expressed on activated T cells and some monocytes. HLA-DQ is absent on hematopoietic progenitors, resting T cells, erythrocytes, and platelets. HLA-DQ is expressed after HLA-DR and HLA-DP in hematopoietic development. HLA-DQ presents peptide fragments mainly from degraded intravesicular and extracellular proteins to CD4+ T lymphocytes. Specific alleles of HLA-DQ have been linked to the pathogenesis of several autoimmune diseases (including diabetes), both as a susceptibility and resistance factor depending on the particular polymorphism.

UniProt: P01906