HMOX1 antibody

Catalog No. ABIN7670621

This Rabbit Polyclonal antibody specifically detects HMOX1 in WB, IHC and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for HMOX1 antibody (ABIN7670621)

Target: HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HMOX1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-HMOX1 Antibody

Purpose: HO1/HMOX1 Polyclonal Antibody

Purification: Antigen Affinity Purification

Immunogen: Recombinant Human HO1/HMOX1 protein expressed by E.coli

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000,IHC 1:500-1:1000,ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for HMOX1

Target: HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))

Alternative Name: HO1/HMOX1

Background: Heme oxygenase 1,HO-1,HMOX1,HO,HO1,EC:1.14.14.18,Heme Oxygenase (HO),also known as HMOX,is the rate limiting enzyme in the breakdown of heme into Biliverdin,CO,and iron. There are two major isoforms of this enzyme,HO-1 and HO-2. Both have similar enzymatic activity,however,HO-1 is rapidly inducible,while HO-2 is constitutively expressed. Inducers of HO-1 include cell stressors such as oxidative stress,infection,hypoxia,and cytotoxic agents. The reaction products generated by HO-1 activity are biologically active,and the enzyme has a broad range of putative roles. For instance,Biliverdin is an antioxidant with cytoprotective and anti-inflammatory properties,and CO has the potential to suppress inflammation and apoptosis. Because of these activities,HO-1 has received much attention as a therapeutic target for a range of pathological processes.

Molecular Weight:

Calculated MW: 33kDa

ObservedMW: 25kDa

UniProt: P09601

Pathways: Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interactome