Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
Storage
4 °C,-20 °C
Storage Comment
Store at 4°C Valid for 1 month or -20°C Valid for 12 months
Expiry Date
12 months
Target
IL-18 (IL18)
(Interleukin 18 (IL18))
Alternative Name
IL-18/IL-1F4
Background
IL18,IL-18, IGIF, IL1F4,Iboctadekin,Interferon gamma-inducing factor,InterLeukin-1 gamma (IL-1 gamma),Pro-inflammatory cytokine primarily involved in epithelial barrier repair,polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses.Upon binding to Il18R1 and Il18RAP,forms a signaling ternary complex which activates NF-kappa-B,triggering synthesis of inflammatory mediators.Synergizes with Il12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells.Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.