IL6RA antibody

Catalog No. ABIN7670672

This Goat Polyclonal antibody specifically detects IL6RA in ELISA. It exhibits reactivity toward Mouse.

Quick Overview for IL6RA antibody (ABIN7670672)

Target: IL6RA (Interleukin 6 Receptor, alpha (IL6RA))

Reactivity: Mouse

Host: Goat

Clonality: Polyclonal

Conjugate: This IL6RA antibody is un-conjugated

Application: ELISA

Product Details anti-IL6RA Antibody

Purpose: IL-6R alpha Polyclonal Antibody(Capture/Detector)

Purification: Antigen Affinity Purification

Immunogen: Recombinant Mouse IL-6R alpha ra Protein expressed by Mammalian

Isotype: IgG

Application Details

Application Notes: ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for IL6RA

Target: IL6RA (Interleukin 6 Receptor, alpha (IL6RA))

Alternative Name: IL-6R alpha

Background: InterLeukin-6 receptor subunit aLpha,IL-6 receptor subunit aLpha,IL-6R subunit aLpha,IL-6R-aLpha,IL-6RA,IL-6R 1,Part of the receptor for interleukin 6. Binds to Il6 with low affinity,but does not transduce a signal. Signal activation necessitate an association with Il6ST. Activation leads to the regulation of the immune response,acute-phase reactions and hematopoiesis. The interaction with membrane-bound Il6R and Il6ST stimulates 'classic signaling',the restricted expression of the Il6R limits classic Il6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of Il6 and soluble Il6R to Il6ST stimulates 'trans-signaling'. Alternatively,'cluster signaling' occurs when membrane-bound Il6:Il6R complexes on transmitter cells activate Il6ST receptors on neighboring receiver cells.

UniProt: P22272

Pathways: JAK-STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints