PTX3 antibody

Catalog No. ABIN7670715

The Rabbit Polyclonal anti-PTX3 antibody has been validated for ELISA. It is suitable to detect PTX3 in samples from Rat.

Quick Overview for PTX3 antibody (ABIN7670715)

Target: PTX3 (Pentraxin 3 (PTX3))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTX3 antibody is un-conjugated

Application: ELISA

Product Details anti-PTX3 Antibody

Purpose: Pentraxin 3/TSG-14 Polyclonal Antibody(Capture/Detector)

Purification: Antigen Affinity Purification

Immunogen: Recombinant Rat Pentraxin 3/TSG-14 protein expressed by E.coli

Isotype: IgG

Application Details

Application Notes: ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for PTX3

Target: PTX3 (Pentraxin 3 (PTX3))

Alternative Name: Pentraxin 3/TSG-14

Background: Ptx3,Ptx-3,Pentraxin 3,Pentraxin 3 (PTX3),TSG-14,was initially identified as a TNF-alpha or Il-1 beta inducible gene. It belongs to the pentraxin family,which was named originally for the homo-pentameric structure formed by its members. The pentraxin family is divided into two subfamilies: the ""short"" and the ""long"" pentraxins with approximate molecular weights of 25 kDa and 50 kDa,respectively. TSG-14 is a member of the long pentraxin subfamily,which also includes the Xenopus laevis Xl-PXN1,the guinea pig apexin/p50,the rat neuronal pentraxin I (NPI) and NPR,the human neuronal pentraxin II (NPTX2) and the human neuronal activity-related pentraxin.Mature secreted TSG-14 contains a pentaxin-like domain at its carboxy-terminus that shares 23?28 % amino acid (aa) sequence similarity to C-reactive protein (CRP) and serum amyloid P component (SAP),which belongs to the short pentraxin subfamily. However,the N-terminal sequence of TSG-14 does not share aa sequence homology with any of the ""short"" pentaxins. Unlike CRP and SAP,which forms pentamers only,TSG-14 forms both pentameric and higher ordered oligomers. Similarly to CRP and SAP,TSG-14 binds to the complement cascade component C1q. However,TSG-14 does not bind to phosphoethanolamine,phosphocholine,or high pyruvate agarose,which are known ligands for CRP and SAP. TSG-14 is a marker of the acute phase response and is highly expressed in advanced atherosclerotic plaques. While CRP and SAP are primarily produced in the liver,TSG-14 expression is strongly up?regulated by TNF-alpha,Il-1 beta,and bacterial lPS in peripheral fibroblasts,endothelial cells,and macrophages.

UniProt: D3ZT94