PLAU antibody

Catalog No. ABIN7670721

The Rat Monoclonal anti-PLAU antibody has been validated for ELISA (Detection). It is suitable to detect PLAU in samples from Human.

Quick Overview for PLAU antibody (ABIN7670721)

Target: PLAU (Plasminogen Activator, Urokinase (PLAU))

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This PLAU antibody is un-conjugated

Application: ELISA (Detection)

Clone: 9B8

Product Details anti-PLAU Antibody

Purpose: Plasminogen Activator/Urokinase Monoclonal Antibody(Detector)

Purification: Protein A/G Purification

Immunogen: Recombinant Human Plasminogen Activator/Urokinase protein expressed by Mammalian

Isotype: IgG1

Application Details

Application Notes: ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for PLAU

Target: PLAU (Plasminogen Activator, Urokinase (PLAU))

Alternative Name: Plasminogen Activator/Urokinase

Background: UPA,u-PA,ATF,URK,UP-A,Urokinase,Abbokinase,This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UniProt: P00749

Pathways: Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration