SNCA antibody

Catalog No. ABIN7670751

The Rat Monoclonal anti-SNCA antibody has been validated for ELISA (Detection). It is suitable to detect SNCA in samples from Human.

Quick Overview for SNCA antibody (ABIN7670751)

Target: SNCA (Synuclein, alpha (SNCA))

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This SNCA antibody is un-conjugated

Application: ELISA (Detection)

Clone: 4H12

Product Details anti-SNCA Antibody

Purpose: alpha-Synuclein/SNCA Monoclonal Antibody(Detector)

Purification: Protein A/G Purification

Immunogen: Recombinant Human alpha-Synuclein/SNCA protein expressed by E.coli

Isotype: IgM

Application Details

Application Notes: ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for SNCA

Target: SNCA (Synuclein, alpha (SNCA))

Alternative Name: alpha-Synuclein/SNCA

Background: SNC-A,aSYN,PD1,NACP,PARK1,PARK4,Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

UniProt: P37840

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity