FAS antibody

Catalog No. ABIN7670753

This Rat Monoclonal antibody specifically detects FAS in ELISA (Detection). It exhibits reactivity toward Human.

Quick Overview for FAS antibody (ABIN7670753)

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This FAS antibody is un-conjugated

Application: ELISA (Detection)

Clone: 7D3

Product Details anti-FAS Antibody

Purpose: Fas/TNFRSF6/CD95 Monoclonal Antibody(Detector)

Purification: Protein A/G Purification

Immunogen: Recombinant Human Fas/TNFRSF6/CD95 protein expressed by E.coli

Isotype: IgG1

Application Details

Application Notes: ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for FAS

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Alternative Name: Fas/TNFRSF6/CD95

Background: FASR,TNFRSF6,APO1,APT1,FAS1,FASTM,ALPS1A,FAS,also named as CD95,APO-1,APT1,FAS1 and TNFRSF6,is a receptor for TNFSF6/FASLG. It is a cell surface receptor belonging to the TNF receptor superfamily,can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains,leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance,in the antigen-stimulated suicide of mature T-cells,or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). This anti-Fas monoclonal antibody can be used to induce apoptosis in cell cultures through Fas by imitating the Fas-ligand.

UniProt: P25445

Pathways: p53 Signaling, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity