VCAM1 antibody

Catalog No. ABIN7670763

The Rabbit Polyclonal anti-VCAM1 antibody has been validated for WB, IHC and ELISA. It is suitable to detect VCAM1 in samples from Human, Mouse and Rat.

Quick Overview for VCAM1 antibody (ABIN7670763)

Target: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VCAM1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-VCAM1 Antibody

Purpose: VCAM-1/CD106 Polyclonal Antibody(Capture/Detector)

Purification: Antigen Affinity Purification

Immunogen: Recombinant Rat VCAM-1/CD106 protein expressed by Mammalian

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000,IHC 1:1000-1:2000,ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for VCAM1

Target: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Alternative Name: VCAM-1/CD106

Background: CD106,Vcam1,Vcam-1,V-CAM 1,VascuLar ceLL adhesion protein 1,SoLubLe VascuLar CeLL Adhesion MoLecuLe-1,Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses,binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Serves also as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation.

Molecular Weight:

Calculated MW: 81kDa

ObservedMW: 75-100kDa

UniProt: P29534

Pathways: Carbohydrate Homeostasis